Inversions come with breakpoints!

Congratulations to Romain Villoutreix for this thorough review of supergene structure. Supergenes are classically thought to be formed by the capture of several previously recombining functional mutations. An alternative model is to consider rearrangement breakpoints as a major mutation that comes automatically in LD with the mutations on the DNA strand on which the rearragement occurs. The latter model may overcome some theoretical difficulties of the classic model necessitating several mutations to segregate in the population prior to being locked into an inversion, and acknowledges the functional effects of many breakpoints.